![]() This is true for parenterally, topically and orally administered solutions. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for drugs. There are many techniques which are used to enhance the aqueous solubility. Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. A success of formulation depends on how efficiently it makes the drug available at the site of action. The deep study is required to prevent the limitation of any method. In recent years, a great deal of knowledge has been accumulated about solid dispersion technology, but other methods like micronization, complexation, pro-drugs concepts also useful in pharmaceutical operations. But Solid dispersion systems have been realized as extremely useful tool in improving the dissolution properties of poorly water-soluble drugs. There are many methods and procedures available to improve the solubility and enhance bioavailability. Finally, a simple justification, which was both qualitative and quantitative, was carried out. Although it was not the objective of this work, the solubility values were qualitatively correlated with several properties of the solvent and solute. If the molality of saturation is not sufficiently small, the ion−ion and ion−solvent interactions must be considered. The solubility of an electrolyte in a given solvent depends on both the nature of the solvent (mainly the polarity, dielectric constant, solvation, or preferential solvation if the solvent is a mixture of solvents, etc.) and the properties of the electrolyte (principally the size, the charge, and the possible association of its ions). ![]() In all cases, the solubility of the electrolytes was decreased significantly in the presence of a cosolvent. ![]() The solubility data for sodium halides (NaF, NaCl, NaBr, and NaI) have been determined at 298.15 K in the ε-increasing mixtures of water−formamide, water−N-methylformamide, and water−N-methylacetamide.
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